In SA we have Rio(Cowdypac), Guarulhos(Bluesky) and Bogota(Jetblue).
I have a gigantic domestic network in Brazil, so your pax would probably have almost every destination in Brazil covered but a lot of flights are filled to capacity already (most airports are too small to anything bigger than an 767), but you could probably make a lot of money from that.
Lima would be nice, in the earlier days I almost risked opening a base there but I had no way to compete with you and didn't try it.
At the moment, I'm doing a big reorganization since I got #1 in Brazil and Italy, my profit margin is only ~10% because I was focusing in quantity and not profit, so I'm getting rid of some not so profitable routes to have a higher margin and don't want to expand right now.